CP868596 cas:670220-88-9

Crenolanib(CP-868596,ARO 002)is a potent and selective inhibitor of PDGFRα/βwith Kd of 2.1 nM/3.2 nM in CHO cells,also potently inhibits FLT3,sensitive to D842V mutation not V561D mutation,>100-fold more selective for PDGFR than c-Kit,VEGFR-2,TIE-2,FGFR-2,EGFR,erbB2,and Src.Crenolanib helps to induce mitophagy.

msds---CP868596